Recombinant allergen-based provocation testing
نویسندگان
چکیده
منابع مشابه
Local and systemic effects of cat allergen nasal provocation.
BACKGROUND Cat allergen is widely distributed in homes and schools; allergic sensitization is common. OBJECTIVE To develop a model of cat allergen nasal challenge to establish dose-response and time-course characteristics and investigate local and systemic biomarkers of allergic inflammation. METHODS Nineteen cat-allergic individuals underwent titrated nasal challenge, range 0.243 to 14.6 μ...
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Regulatory T cells (Tregs) play a non-redundant role in maintenance of immune homeostasis. This is achieved by suppressing both, priming of naı̈ve cells and effector cell functions. Although Tregs have been implicated in modulating allergic immune responses, their influence on distinct phases of development of allergies remains unclear. In this study, by using bacterial artificial chromosome (BA...
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Currently, AIT represents the sole allergen-specific therapeutic approach dealing with IgE-mediated allergic disease able to control not only its symptoms, as other treatments do, but also to rebalance the immunological profile of allergic subjects. In fact, they develop detrimental immune responses towards allergens, exogenous proteins that should be otherwise harmless, entering the body from ...
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Allergic diseases are among the most common health issues worldwide. Specific immunotherapy has remained the only disease-modifying treatment, but it is not effective in all patients and may cause side effects. Over the last 25 years, allergen molecules from most prevalent allergen sources have been isolated and produced as recombinant proteins. Not only are these molecules useful in improved a...
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INTRODUCTION Optical rhinometry (ORM) is a technique that allows for direct continuous measurement of changes in blood flow (optical density) in nasal vessels, at the same time analyzing changes per unit of time in the evaluated variable: intravascular blood flow and oxygen saturation. AIM To assess the extent to which ORM can be used as an objective measure of nasal mucosal edema following a...
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ژورنال
عنوان ژورنال: Methods
سال: 2014
ISSN: 1046-2023
DOI: 10.1016/j.ymeth.2013.07.037